Stay calm - this is usually a deliberate test of whether you defend numbers blindly or reason about them.
1. Do not immediately capitulate or dig in. Both are wrong. Say: "Let me re-check the assumption that drives it."
2. Re-derive out loud, isolating each input. A 10x error almost always comes from one of a small set of causes:
3. Separate arithmetic errors from assumption disagreements. If the arithmetic is wrong, fix it and thank them. If they simply assume different inputs, say so explicitly: "My maths holds for 10 actions per user. If it is 100, everything scales up 10x - and that changes the design, because at that point one cache node is no longer enough."
4. Show what the correction changes. The most valuable response is: "With the corrected number, my earlier conclusion that we could fit this in one database no longer holds - I would need to shard." That demonstrates the estimate was actually load-bearing rather than decorative.